The anti-hyperlipidemic and anti-inflammatory effects exerted by Aloe on monogastric mammals suggest it as a potential strategy to address the tremendous metabolic alterations that affect dairy cows during their transition to calving. A group of 20 multiparous Italian Holstein dairy cows were housed in freestalls and allocated into two homogeneous groups to receive either 200 g/d of water (CTR) or 200 g/day of Aloe arborescens Mill. whole plant homogenate through a rumen tube (AAM) between −14 and 14 days from calving (DFC). From −14 to 35 DFC, the BCS, and milk yield were measured, and blood samples were collected to assess the hematochemical profile. Data underwent ANOVA testing using a mixed model for repeated measurements, including the treatment and time and their interactions as fixed effects. Compared to CTR cows, AAM cows had a less pronounced BCS loss in early lactation (p < 0.01), indicating less mobilization of body reserves. Compared to CTR cows, AAM cows had a lower plasma concentration of nonesterified fatty acids and beta hydroxybutyrate (p < 0.01 and = 0.01 respectively) that, paired with the lower butterfat content and fat/protein ratio in their milk (p = 0.03 and < 0.01 respectively), indicates that Aloe reduced the mobilization of body fats. AAM cows had a reduced concentration of myeloperoxidase in plasma and a lower SCC in milk compared to CTR cows (p = 0.02 for both), indicating an anti-inflammatory effect of Aloe. Furthermore, AAM cows had a lower plasma concentration of ceruloplasmin (p < 0.05) and higher plasma concentration of cholesterol, retinol, and paraoxonase compared to CTR cows (p < 0.01, < 0.01 and < 0.05 respectively), indicating Aloe was effective in mitigating the acute phase response in early lactation. Finally, AAM cows had lower plasma creatinine concentrations around calving (p < 0.05), a lower concentration of plasma bilirubin, and a higher concentration of plasma tocopherol compared to CTR cows (p = 0.01 for both). These data suggest Aloe has anti-hyperlipidemic and anti-inflammatory effects on transition dairy cows that could have ameliorated liver and kidney function disruption and increased the availability of body antioxidants in early lactation.

中文翻译：

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过渡时期芦荟全植物匀浆对奶牛脂质代谢，炎症状况和肝功能的影响。

芦荟对单胃哺乳动物的降血脂和抗炎作用表明，它是解决奶牛向犊牛过渡期间影响奶牛的巨大代谢变化的潜在策略。一组20只意大利荷斯坦奶牛产于冻土中，分为两组，分别接受200克/天的水（CTR）或200克/天的芦荟磨。产犊（DFC）后的14到14天之间，整株植物通过瘤胃管（AAM）匀浆。在-14至35 DFC之间，测量了BCS和牛奶产量，并收集了血液样本以评估血液化学特征。使用混合模型对数据进行ANOVA测试以进行重复测量，包括治疗和时间及其相互作用（作为固定效应）。与CTR奶牛相比，AAM奶牛在泌乳初期的BCS损失较少（p <0.01），表明其身体储备的动员较少。与CTR奶牛相比，AAM奶牛的非酯化脂肪酸和β羟基丁酸酯的血浆浓度较低（分别为p <0.01和= 0.01），与牛奶中的低脂脂肪含量和脂肪/蛋白质比率较低（p分别等于0.03和<0.01），表明芦荟减少了人体脂肪的运动。与CTR奶牛相比，AAM奶牛血浆中的髓过氧化物酶浓度降低，而牛奶中的SCC较低（两者均为p = 0.02），表明芦荟具有抗炎作用。此外，与CTR奶牛相比，AAM奶牛的血浆铜蓝蛋白浓度较低（p <0.05），胆固醇，视黄醇和对氧磷酶的血浆浓度较高（分别为p <0.01，<0.01和<0.05），表明芦荟可以有效缓解哺乳早期的急性期反应。最后，AAM母牛产犊前后血浆肌酐浓度较低（p<0.05），血浆胆红素浓度较低，血浆生育酚浓度较高（与CTR奶牛相比，两者均p = 0.01）。这些数据表明，芦荟对过渡型奶牛具有降血脂和抗炎作用，可以改善肝脏和肾脏功能破坏，并在早期哺乳期增加人体抗氧化剂的利用率。