The formation of gas hydrates in offshore subsea lines is a major flow assurance concern for the oil and gas industry. In this work, the thermodynamic hydrate inhibition (THI) effect of doping amino acids (AA) such as glycine (Gly), l‐alanine (Ala), and histidine (His) with classical gas hydrate inhibitors (CHI) such as methanol (Me), ethylene glycol (EG), and sodium chloride (NaCl) have been examined at diverse operating conditions. The experimental tests were carried out using rocking cell assembly [RC‐5] on pure methane gas at different pressure conditions (40–120 bars) using an equal ratio mixture (1:1) of AA and CHI at a low dosage (2 wt%). The computational three‐dimensional molecular models of AA and CHI were generated to examine electric charge distribution within these molecules and cognize the interaction mechanism between methane hydrates and AA. The experimental results indicate that Me and EG can synergize the THI effect of AA at a low dosage of 1 wt%. The AA doped with Me tend to provide better THI effect compared to AA doped with EG and NaCl. The experimental results also show that the doped AA Ala mixtures provide THI effect similar to pure CHI such as Me, EG, and NaCl at low dosage (2 wt%). © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd.

中文翻译：

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用经典的气体水合物抑制剂掺杂氨基酸以促进低剂量时的水合物抑制作用

在海底海底管线中形成天然气水合物是石油和天然气行业主要的流量保证问题。在这项工作中，掺杂氨基酸（AA）的甘氨酸（Gly），l的热力学水合物抑制（THI）作用丙氨酸（Ala）和组氨酸（His）与经典的气体水合物抑制剂（CHI），例如甲醇（Me），乙二醇（EG）和氯化钠（NaCl）已在不同的操作条件下进行了测试。实验测试是在不同压力条件（40–120 bar）下，使用摇室组件[RC-5]在纯甲烷气体上，使用低剂量（2 wt％）的AA和CHI的等比例混合物（1：1）进行的。 ％）。生成了AA和CHI的三维计算分子模型，以检查这些分子中的电荷分布，并了解甲烷水合物与AA之间的相互作用机理。实验结果表明，Me和EG可以在1 wt％的低剂量下协同AA的THI效应。与掺有EG和NaCl的AA相比，掺有Me的AA倾向于提供更好的THI效果。实验结果还表明，掺杂的AA Ala混合物在低剂量（2 wt％）下提供类似于纯CHI（例如Me，EG和NaCl）的THI效果。©2020年化学工业协会和John Wiley＆Sons，Ltd.