Overexpression of the transcription factors OCT4 and KLF4 improves motor function after spinal cord injury.,CNS Neuroscience & Therapeutics

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Overexpression of the transcription factors OCT4 and KLF4 improves motor function after spinal cord injury.
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2020-05-25 , DOI: 10.1111/cns.13390
Xianpeng Huang _{1,

2} , Chenggui Wang _{1,

2} , Xiaopeng Zhou _{1,

2} , Jingkai Wang _{1,

2} , Kaishun Xia _{1,

2} , Biao Yang _{1,

2} , Zhe Gong _{1,

2} , Liwei Ying _{1,

2} , Chao Yu _{1,

2} , Kesi Shi _{1,

2} , Jiawei Shu _{1,

2} , Feng Cheng _{1,

2} , Bin Han _{1,

2} , Chengzhen Liang _{1,

2} , Fangcai Li _{1,

2} , Qixin Chen _{1,

2}

Affiliation

Astrogliosis and glial scar formation following spinal cord injury (SCI) are viewed as major obstacles that hinder axonal regeneration and functional recovery. Regulating the glial scar and axonal regeneration in the lesion site is important for treating SCI.

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