Non‐small‐cell lung carcinoma (NSCLC) continues to top the list of cancer mortalities worldwide. The role of circular RNAs (circRNAs) in tumorigenesis has been increasingly appreciated, although it is relatively unexplored in NSCLC. Herein, we reported the role of hsa_circ_0085131 in NSCLC. In the present study, NSCLC tumor specimens exhibited a higher hsa_circ_0085131 level in comparison to para‐tumor samples. And the higher level of hsa_circ_0085131 was associated with recurrence and poorer survival of NSCLC. Moreover, hsa_circ_0085131 promoted cell proliferation and cisplatin (DDP)‐resistance. Furthermore, hsa_circ_0085131 regulated cell DDP‐resistance by modulating autophagy. Hsa_circ_0085131 acted as a competing endogenous RNA of miR‐654‐5p to release autophagy‐associated factor ATG7 expression, thereby promoting cell chemoresistance. In conclusion, hsa_circ_0085131 enhances DDP‐resistance of NSCLC cells through sequestering miR‐654‐5p to upregulate ATG7, leading to cell autophagy. Therefore, these findings advocate targeting the hsa_circ_0085131/miR‐654‐5p/ATG7 axis as a potential therapeutic option for patients with NSCLC who are resistant to DDP.

中文翻译：

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环状RNA hsa_circ_0085131通过调节自噬参与非小细胞肺癌细胞的顺铂耐药。


非小细胞肺癌（NSCLC）继续位居全球癌症死亡率之首。环状 RNA (circRNA) 在肿瘤发生中的作用越来越受到重视，尽管它在 NSCLC 中的研究相对较少。在此，我们报道了 hsa_circ_0085131 在 NSCLC 中的作用。在本研究中，与肿瘤旁样本相比，NSCLC 肿瘤样本表现出更高的 hsa_circ_0085131 水平。 hsa_circ_0085131水平较高与NSCLC的复发和较差的生存率相关。此外，hsa_circ_0085131 促进细胞增殖和顺铂 (DDP) 耐药。此外，hsa_circ_0085131 通过调节自噬来调节细胞 DDP 抗性。 Hsa_circ_0085131作为miR-654-5p的竞争性内源RNA，释放自噬相关因子ATG7表达，从而促进细胞化疗耐药。总之，hsa_circ_0085131 通过隔离 miR-654-5p 上调 ATG7 增强 NSCLC 细胞的 DDP 抗性，从而导致细胞自噬。因此，这些发现主张针对 hsa_circ_0085131/miR-654-5p/ATG7 轴作为对 DDP 耐药的 NSCLC 患者的潜在治疗选择。