当前位置: X-MOL 学术Cell Biol. Int. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A review of the chemopreventative and chemotherapeutic properties of the phytochemicals berberine, resveratrol and curcumin, and their influence on cell death via the pathways of apoptosis and autophagy.
Cell Biology International ( IF 3.9 ) Pub Date : 2020-05-25 , DOI: 10.1002/cbin.11402
Mark Sean D'Arcy 1
Affiliation  

Phytochemicals are a diverse group of compounds found in a variety of fruits, vegetables and herbs, and have been reported to possess a number of health benefits. Marketed as supplements by health food retailers, this group of naturally occurring compounds have been investigated for a number of years to determine if they possess any chemopreventative and/or chemotherapeutic benefits. In this comprehensive review, the phytochemicals resveratrol, berberine and curcumin will be discussed, with particular focus being given to their proposed anticancer applications. The purpose of this review is to help clarify whether there is any truth in the claims that are regularly made regarding the efficacy of these compounds. To this end, a number of significant studies that involved the use of these phytochemicals will be identified, discussed and evaluated, to determine if they show promise in the ongoing fight to reduce the incidence rates and severity of various cancers. Specifically, it is the aim of this review to present and discuss key studies performed over the last two decades using these compounds and to evaluate, compare and contrast their effectiveness as chemopreventatives and chemotherapeutics. This should provide the reader with an overarching picture of how these structurally similar phytochemicals might be used in both clinical and nonclinical settings, as a part of the ongoing effort by clinicians, to help to slow down the increasing rate of cancers observed over the last few decades.

中文翻译:

植物小碱,白藜芦醇和姜黄素的化学预防和化学治疗性质及其通过细胞凋亡和自噬途径对细胞死亡的影响的综述。

植物化学物质是在各种水果,蔬菜和草药中发现的多种化合物,据报道具有许多健康益处。由保健食品零售商作为补充剂销售的这类天然化合物已进行了多年研究,以确定它们是否具有任何化学预防和/或化学治疗益处。在这篇综合综述中,将讨论植物化学物质白藜芦醇,小ber碱和姜黄素,并将重点放在其拟议的抗癌应用上。这篇综述的目的是帮助阐明定期提出的关于这些化合物功效的权利要求中是否存在任何真相。为此,将鉴定,讨论和评估许多涉及使用这些植物化学物质的重要研究,确定它们在减少各种癌症的发生率和严重性的持续斗争中是否显示出希望。具体地说,本综述的目的是介绍和讨论过去二十年来使用这些化合物进行的关键研究,并评估,比较和对比其作为化学预防剂和化学疗法的有效性。这应该为读者提供一张有关如何在临床和非临床环境中使用这些结构相似的植物化学物质的总体图片,作为临床医生正在进行的工作的一部分,以帮助减缓在过去的几年中观察到的癌症的增长速度几十年。这篇综述的目的是介绍和讨论过去二十年来使用这些化合物进行的关键研究,并评估,比较和对比其作为化学预防剂和化学治疗剂的有效性。这应该为读者提供一张有关如何将这些结构相似的植物化学物质用于临床和非临床环境的总体图片,这是临床医生正在进行的努力的一部分,以帮助减缓在过去的几年中观察到的癌症发病率几十年。这篇综述的目的是介绍和讨论过去二十年来使用这些化合物进行的关键研究,并评估,比较和对比其作为化学预防剂和化学治疗剂的有效性。这应该为读者提供一张有关如何在临床和非临床环境中使用这些结构相似的植物化学物质的总体图片,作为临床医生正在进行的工作的一部分,以帮助减缓在过去的几年中观察到的癌症的增长速度几十年。
更新日期:2020-05-25
down
wechat
bug