mPGES1 catalyses the production of PGE₂, the most abundant prostanoid related to inflammation and pain in arthritis. mPGES1 is suggested to be a safer and more selective drug target in inflammatory conditions compared to the COX enzymes inhibited by NSAIDs. In the present study, we investigated the effects of the selective mPGES1 inhibitor MF63 on gene expression in primary human chondrocytes from patients with osteoarthritis (OA).

中文翻译：

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MF63对基因表达的调控，MF63是人骨关节炎软骨细胞中微粒体PGE合酶1（mPGES1）的选择性抑制剂。

mPGES1催化PGE ₂的产生，PGE ₂是与关节炎的炎症和疼痛相关的最丰富的类前列腺素。与NSAIDs抑制的COX酶相比，mPGES1被认为是炎性疾病中更安全，更具选择性的药物靶标。在本研究中，我们调查了选择性mPGES1抑制剂MF63对骨关节炎（OA）患者原代人软骨细胞基因表达的影响。