Chemotherapy-induced immune-suppression is a common, but potential detrimental, adverse reaction in patients undergoing treatment for cancer and strategies with capacity to boost the immune cell populations are needed. Physical exercise training is a potent regulator of immune cell viability and function and may serve as a viable, non-pharmacological prophylactic strategy in addition to the current pharmacological management by, for example, granulocyte-colony stimulating factor (G-CSF). Here, we review the mechanistic evidence linking exercise training to haematopoietic function and subsequent possible amelioration of chemotherapy-related neutropenia. First, we briefly describe neutrophil regulation and management of neutropenia in cancer patients. Second, we summarize the effect of acute and chronic exercise training on neutrophils and their progenitors, and finally, we outline the current clinical evidence of exercise interventions in ongoing anti-cancer treatment in regard to neutropenia incidence, treatment tolerance and related outcomes.

中文翻译：

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运动训练作为化疗期间中性粒细胞减少症管理的预防策略

化疗诱导的免疫抑制是接受癌症治疗的患者的常见但潜在有害的不良反应，需要能够增强免疫细胞群的策略。体育锻炼训练是免疫细胞活力和功能的有效调节剂，除了目前通过例如粒细胞集落刺激因子 (G-CSF) 进行的药理学管理外，还可以作为一种可行的非药理学预防策略。在这里，我们回顾了将运动训练与造血功能以及随后可能改善化疗相关的中性粒细胞减少症联系起来的机制证据。首先，我们简要描述了癌症患者中性粒细胞减少症的中性粒细胞调节和管理。第二，