CRISPR activation (CRISPRa) in bacteria is an attractive method for programmable gene activation. In article number 1900252, Yang Liu and Baojun Wang summarize the current state‐of‐the‐art in this area of high potential, and present the powerful features and capabilities of a newly reported eukaryote‐like, σ⁵⁴‐dependent CRISPRa system. The eukaryote‐like bacterial CRISPRa enables novel designs in synthetic gene regulation and promotes research in the σ⁵⁴‐dependent gene networks with broad applications envisioned.

中文翻译：

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BioEssays 6/2020

细菌中的CRISPR激活（CRISPRa）是一种有吸引力的可编程基因激活方法。在文章编号1900252，杨和宝骏王总结当前国家的最先进的在这方面的高电位，并呈现强大的功能和新报告的真核生物样，σ能力⁵⁴依赖性CRISPRa系统。真核生物状细菌CRISPRa使得能够在合成基因调控新颖的设计，并在σ促进研究^54个具有广阔的应用依赖的基因网络可以预见的。