Nickel-Catalyzed Allylmethylation of Alkynes with Allylic Alcohols and AlMe3 : Facile Access to Skipped Dienes and Trienes.,Angewandte Chemie International Edition

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Nickel-Catalyzed Allylmethylation of Alkynes with Allylic Alcohols and AlMe3 : Facile Access to Skipped Dienes and Trienes.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-05-25 , DOI: 10.1002/anie.202006322
Wanfang Li ₁ , Shun Yu ₂ , Jincan Li ₁ , Yu Zhao _{2,

3}

Affiliation

We present herein an unprecedented allylative dicarbofunctionalization of alkynes with allylic alcohols. This simple catalytic procedure utilizes commercially available Ni(COD)₂, triphenylphosphine, and inexpensive reagents, and delivers valuable skipped dienes and trienes with an all‐carbon tetrasubstituted alkene unit in a highly stereoselective fashion. Preliminary mechanistic studies support the reaction pathway of allylnickelation followed by transmetalation in this dicarbofunctionalization of alkynes.

中文翻译：

炔烃与烯丙醇和AlMe3的镍催化烯丙基甲基化：容易获得跳过的二烯和三烯。

我们在本文中提出了炔烃与烯丙醇的前所未有的烯丙基二碳官能化。这种简单的催化程序利用市售的Ni（COD）₂，三苯基膦和廉价的试剂，并以高度立体选择性的方式提供了具有全碳四取代烯烃单元的有价值的跳过的二烯和三烯。初步的机理研究支持在炔烃的这种双碳官能化中烯丙基镍化反应然后进行金属转移的反应途径。

更新日期：2020-05-25

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