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Multiplex Spatial Bioimaging for Combination Therapy Design.
Trends in Cancer ( IF 18.4 ) Pub Date : 2020-05-25 , DOI: 10.1016/j.trecan.2020.05.003
Shuangyi Cai 1 , Mayar Allam 1 , Ahmet F Coskun 2
Affiliation  

Multiplex spatial analyses dissect the heterogeneous cellular abundances and interactions in tumors. Single-cell bioimaging profiles many disease-associated protein biomarkers in patient biopsies to inform the design of cancer therapies. Guided by the mechanistic insights from spatial cellular maps, combination therapy can efficiently eliminate cancers with reduced off-targets, resistance, and relapse.



中文翻译:

用于联合治疗设计的多重空间生物成像。

多重空间分析剖析了肿瘤中的异质细胞丰度和相互作用。单细胞生物成像分析了患者活检中许多疾病相关的蛋白质生物标志物,为癌症疗法的设计提供信息。在空间细胞图的机制见解的指导下,联合治疗可以有效地消除癌症,减少脱靶、耐药和复发。

更新日期:2020-05-25
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