Background

Intrauterine Zika virus (ZIKV) infection is associated with neurological disorders and other problems such as impaired visual and hearing function, and orthopedic abnormalities, including arthrogryposis. We systematically investigated the prevalence of arthrogryposis in infants with congenital Zika syndrome (CZS) and respective risk of mortality.

Methods

We conducted a systematic review and meta-analysis of reports published in PubMed, Web of Science, SCOPUS, and World Health Organization Global Index Medicus databases, using the keywords Zika virus and arthrogryposis and related terms.

Results

After screening titles and abstracts, a total of four studies were included. Arthrogryposis was not associated with increased risk for fetal demise (RR 3.33; 95%CI 0.73 to 15.26). However, arthrogryposis was associated with a 13-fold increased risk of mortality in neonates with CZS (RR = 13.11; 95%CI 3.74 to 45.92) than neonates with CZS but without arthrogryposis.

Conclusion

Neonates with both CZS and arthrogryposis had higher morbidity and mortality risks, making it necessary to implement protocols for the early identification of neuromuscular changes as well as for the appropriate management of patients.

中文翻译：

---

先天性寨卡综合症婴儿的关节炎与死亡率之间的关联：系统评价和荟萃分析。

背景

宫内寨卡病毒（ZIKV）感染与神经系统疾病和其他问题有关，例如视觉和听觉功能受损以及整形外科异常，包括关节炎。我们系统地调查了先天性寨卡综合征（CZS）婴儿的关节置换的患病率和相应的死亡风险。

方法

我们对在PubMed，Web of Science，SCOPUS和世界卫生组织Global Index Medicus数据库中发布的报告进行了系统的回顾和荟萃分析，使用了关键词Zika病毒和关节炎和相关术语。

结果

在筛选标题和摘要后，总共包括四项研究。关节囊变与胎儿死亡的风险增加无关（RR 3.33； 95％CI 0.73至15.26）。然而，与CZS但无关节炎的新生儿相比，CZS新生儿的关节炎与死亡风险增加了13倍（RR = 13.11； 95％CI 3.74至45.92）。

结论

患有CZS和关节炎的新生儿都有较高的发病率和死亡率风险，因此有必要实施方案，以尽早发现神经肌肉变化并进行适当的患者治疗。