Abstract A series of N-arylfluorinated hydroxylated-Schiff bases were synthesized in a facile and high yield manner. The compounds were fully characterized including the unequivocal determination of the structure of two derivatives (2 and 4) by single crystal X-ray diffraction analysis. Preliminary in vitro antiparasitic activity against an endemic Trypanosoma cruzi strains in Mexico (NINOA) showed these compunds to have better trypanocidal activity compared to the reference drugs Nifurtimox (Nfx) and Benznidazole (Bnz).

中文翻译：

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N-芳基氟化羟基化-席夫碱的合成、表征和初步体外杀锥虫活性

摘要 以简便、高收率的方式合成了一系列N-芳基氟化羟基化席夫碱。对化合物进行了全面表征，包括通过单晶 X 射线衍射分析明确确定了两种衍生物（2 和 4）的结构。针对墨西哥地方性克氏锥虫菌株 (NINOA) 的初步体外抗寄生虫活性表明，与参考药物 Nifurtimox (Nfx) 和苯硝唑 (Bnz) 相比，这些化合物具有更好的杀锥虫活性。