Abstract The vibrational spectra of the ranitidine hydrochloride have been studied using Raman spectroscopy at pressures up to 11.2 GPa. At a pressure above 1.2 GPa a polymorphic phase transition from the initial form II to a new pressure induced form V has been observed. The vibration modes of the ranitidine hydrochloride as functions of pressure have been obtained. At pressures above 6.2 GPa, a gradual transformation to the amorphous phase of ranitidine hydrochloride has been revealed.

中文翻译：

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高压对盐酸雷尼替丁振动谱的影响

摘要 使用拉曼光谱研究了盐酸雷尼替丁的振动光谱，压力高达 11.2 GPa。在高于 1.2 GPa 的压力下，观察到从初始形式 II 到新的压力诱导形式 V 的多晶相转变。已经获得了作为压力函数的雷尼替丁盐酸盐的振动模式。在高于 6.2 GPa 的压力下，已发现盐酸雷尼替丁逐渐转变为无定形相。