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Lipid deposition on contact lenses in symptomatic and asymptomatic contact lens wearers.
Contact Lens & Anterior Eye ( IF 4.1 ) Pub Date : 2020-05-25 , DOI: 10.1016/j.clae.2020.05.006
Negar Babaei Omali 1 , Lakshman N Subbaraman 1 , Miriam Heynen 1 , Mark Lada 2 , Kristy Canavan 2 , Zohra Fadli 2 , William Ngo 1 , Lyndon Jones 1
Affiliation  

Purpose

Lipid deposition on contact lenses (CL) has traditionally been believed to reduce comfort during CL wear. The purpose of this study was to quantify lipid deposition on CL in a group of symptomatic and asymptomatic adapted CL wearers.

Methods

This was a single-masked, randomized clinical trial. Only confirmed symptomatic (comfortable lens wear time (CWT) < 8 h and a noticeable reduction in comfort over the course of the day) and asymptomatic (CWT > 10 h and minimal reduction in comfort over the course of the day) participants were recruited to participate in the study. Participants wore senofilcon A lenses in combination with a polyquaternium-based care solution (OPTI-FREE Replenish). Worn CL samples were collected on Day 14. Deposited lipid amounts from the lenses (including cholesteryl ester, cholesterol and triolein) were quantified using a liquid chromatography-mass spectrometry technique.

Results

Lipid deposition was significantly higher in CL extracts of asymptomatic wearers compared to the symptomatic wearers for all lipid types quantified, including cholesteryl ester (2.1 ± 0.6 vs 1.6 ± 0.5 log μg/lens), cholesterol (1.5 ± 0.3 vs 1.1 ± 0.3 log μg/lens) and triolein (0.3 ± 0.2 vs 0.1 ± 0.1 log μg/lens) (all p < 0.002). The amount of cholesteryl ester deposited was greatest (p = 0.0001), followed by cholesterol, then triolein, for both the asymptomatic and symptomatic groups (both p = 0.0001).

Conclusion

This study demonstrated that the asymptomatic group deposited a significantly greater amount of lipid on their CL. Although lipid levels measured are considered low to trigger any observable clinical deposition, they may influence other clinical outcomes, particularly comfort.



中文翻译:

有症状和无症状隐形眼镜佩戴者的隐形眼镜上的脂质沉积。

目的

传统上认为,隐形眼镜 (CL) 上的脂质沉积会降低佩戴隐形眼镜时的舒适度。本研究的目的是量化一组有症状和无症状的适应 CL 佩戴者的 CL 上的脂质沉积。

方法

这是一项单盲、随机临床试验。仅招募确认有症状(舒适镜片佩戴时间 (CWT) < 8 小时,一天中舒适度显着降低)和无症状(CWT > 10 小时,一天中舒适度降低最小)的参与者参加参与研究。参与者佩戴 senofilcon A 镜片和基于聚季铵盐的护理液 (OPTI-FREE Replenish)。在第 14 天收集磨损的 CL 样品。使用液相色谱-质谱法技术对镜片上沉积的脂质量(包括胆固醇酯、胆固醇和甘油三酯)进行量化。

结果

对于所有量化的脂质类型,包括胆固醇酯(2.1 ± 0.6 vs 1.6 ± 0.5 log μg/镜片)、胆固醇(1.5 ± 0.3 vs 1.1 ± 0.3 log μg ),无症状佩戴者的 CL 提取物中的脂质沉积显着高于有症状佩戴者/lens) 和三油精(0.3 ± 0.2 vs 0.1 ± 0.1 log μg/lens)(所有p < 0.002)。的胆甾醇酯沉积量为最大(p = 0.0001),其次是胆固醇,甘油三油酸酯,然后,为对无症状和有症状团两者(两者p = 0.0001)。

结论

该研究表明,无症状组在其 CL 上沉积了显着更多的脂质。尽管测量的血脂水平被认为是触发任何可观察到的临床沉积的低水平,但它们可能会影响其他临床结果,尤其是舒适度。

更新日期:2020-05-25
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