OBJECTIVE To determine the course of sleep distrurbance (insomnia symptoms and short sleep duration) after a diagnosis of epilepsy and their associations with seizure control, mood, disability, and quality of life. PATIENTS AND METHODS One hundred and sixty-nine adults were drawn from the Sydney Epilepsy Incidence Study to Measure Illness Consequences (SEISMIC), a prospective, multicenter, community-wide study in Sydney, Australia. Socio-demographic, psychosocial, clinical characteristics, and information on sleep disturbance were obtained early (median 48 [IQR15-113] days) after a diagnosis of epilepsy, and at 12 months. Logistic regression models were used to determine associations between patterns of sleep disturbance with outcomes at 12 months. RESULTS Insomnia symptoms and/or short sleep duration were present in 18-23% of participants at both time points, with over half (54-61%) showing a chronic pattern. There was no association of sleep disturbance pattern with recurrent seizures, medication use or disability. Chronic insomnia symptoms and short sleep duration were strongly associated with worse mental health (aOR 3.76, 95% CI 1.28-11.06; and aOR 5.41, 95% CI 1.86-15.79) and poorer quality of life at 12 months (aOR 3.02, 95% CI 1.03-8.84; and aOR 3.11, 95% CI 1.10-8.82), after adjusting for clinical features of epilepsy and comorbidity. Those whose sleep disturbance remitted had no adverse outcomes. CONCLUSIONS Insomnia symptoms and short sleep duration are less common in people with recently-diagnosed than chronic epilepsy. The temporal association with poor psycholosocial outcomes supports specific interventions addressing sleep disturbance.

中文翻译：

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睡眠障碍对新诊断癫痫的过程和影响：一项前瞻性注册研究

目的 确定诊断出癫痫后睡眠障碍（失眠症状和睡眠时间短）的过程及其与癫痫控制、情绪、残疾和生活质量的关系。患者和方法 169 名成年人来自悉尼癫痫发病率研究以测量疾病后果 (SEISMIC)，这是一项在澳大利亚悉尼进行的前瞻性、多中心、社区范围的研究。社会人口学、社会心理、临床特征和睡眠障碍信息是在癫痫诊断后的早期（中位数 48 [IQR15-113] 天）和 12 个月时获得的。Logistic 回归模型用于确定睡眠障碍模式与 12 个月结果之间的关联。结果 在两个时间点，18-23% 的参与者都存在失眠症状和/或睡眠时间短，其中超过一半 (54-61%) 表现出慢性模式。睡眠障碍模式与复发性癫痫发作、药物使用或残疾无关。慢性失眠症状和睡眠时间短与较差的心理健康（aOR 3.76，95% CI 1.28-11.06；和 aOR 5.41，95% CI 1.86-15.79）和 12 个月时较差的生活质量（aOR 3.02，95%）密切相关CI 1.03-8.84；和 aOR 3.11，95% CI 1.10-8.82），在调整癫痫和合并症的临床特征后。那些睡眠障碍得到缓解的人没有不良后果。结论 与慢性癫痫相比，近期诊断出的患者失眠症状和睡眠时间短的情况较少。