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Postpartum paradoxical expansion of cerebrocerebellar lesions associated with Cryptococcus gattii meningoencephalitis
Clinical Neurology and Neurosurgery ( IF 1.8 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.clineuro.2020.105955
Daisuke Ishikawa 1 , Tokuzo Maruyama 1 , Takumi Nakamura 1 , Setsuki Tsukagoshi 1 , Natsumi Furuta 1 , Kazuaki Nagashima 1 , Fumiaki Honda 2 , Yoshio Ikeda 1
Affiliation  

Abstract A 36-year-old immunocompetent pregnant woman with Cryptococcus gattii meningoencephalitis complicated by immune reconstitution inflammatory syndrome (IRIS)-like syndrome was reported. She developed postpartum paradoxical expansion of cerebrocerebellar lesions on MRI after initiation of antifungal therapy, and these lesions were successfully treated by steroid therapy. The potential for postpartum development of IRIS-like syndrome associated with Cryptococcus gattii infection should be recognized. Steroid therapy is effective for managing IRIS-like syndrome, and long-term steroid therapy should be considered in severe conditions.

中文翻译:

加蒂隐球菌脑膜脑炎相关脑小脑病变的产后反常扩大

摘要 报道了一名 36 岁免疫功能正常的孕妇,患有加蒂隐球菌脑膜脑炎并发免疫重建炎症综合征(IRIS)样综合征。在开始抗真菌治疗后,她在 MRI 上出现了产后脑小脑病变的矛盾扩大,这些病变通过类固醇治疗成功治疗。应该认识到与格蒂隐球菌感染相关的 IRIS 样综合征的产后发展潜力。类固醇治疗对治疗 IRIS 样综合征有效,严重时应考虑长期类固醇治疗。
更新日期:2020-09-01
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