Abstract

Hydrogels have been prepared by mixing chitosan and pectin solutions, as well as solutions of their modified derivatives, in aqueous media at room temperature. The gels are obtained within a time period from several seconds to half an hour or more, depending on the process conditions. The hydrogels are formed due to both the covalent bonding between functional groups and the formation of interpolyelectrolyte complexes via the interaction between ammonium groups of chitosan and carboxylate groups of pectin. Conditions have been determined for the hydrogel formation throughout the solution volume without liquid phase separation. The swelling of lyophilized hydrogels has been studied as depending on the ionic strength and pH of aqueous media. The feasibility of prolonged drug release from the developed polymer matrix has been shown by the example of cytostatics, namely, mitomycin C and cisplatin.

中文翻译：

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壳聚糖和果胶基水凝胶的合成及性能

摘要

通过在室温下在水性介质中混合壳聚糖和果胶溶液及其改性衍生物的溶液来制备水凝胶。根据工艺条件，在几秒钟到半小时或更长时间内获得凝胶。由于官能团之间的共价键结合以及经由壳聚糖的铵基团与果胶的羧酸酯基团之间的相互作用，形成了聚电解质间复合物，从而形成了水凝胶。已经确定了在整个溶液体积中没有液相分离的水凝胶形成条件。已经研究了冻干水凝胶的溶胀，取决于水介质的离子强度和pH。