The utility of non-invasive brain stimulation techniques to alleviate resistant delusions in schizophrenia is an under-researched area. In this study, we report the effectiveness of alpha transcranial alternating current stimulation (tACS) targeting the medial prefrontal cortex in ameliorating persistent delusions. Twelve Schizophrenia patients (N=12) with persistent delusions received add-on treatment with a twice-daily 20-minutes session of 10-Hz tACS. Significant reduction in severity of delusion was noted after 5th day (z=2.67, p<0.01, n=12) with further improvement after 10th day (z=2.52, p=0.01, n=9) of stimulation. Add-on treatment with 10-Hz tACS is a potential therapeutic option for treatment-resistant delusions, which requires further systematic research.

非侵入性脑刺激技术在精神分裂症中缓解耐药性妄想的用途尚待研究。在这项研究中，我们报告了针对内侧前额叶皮层的α经颅交流电刺激（tACS）在改善持续性妄想方面的有效性。十二名患有持续性妄想的精神分裂症患者（N = 12）接受了附加治疗，每天两次两次，每次20分钟，频率为10 Hz tACS。第5天后，妄想的严重程度显着降低（z = 2.67，p <0.01，n = 12），第10天后进一步改善（z = 2.52，p = 0.01，n= 9）刺激。10-Hz tACS的附加治疗是治疗抗性妄想的潜在治疗选择，需要进一步的系统研究。