LGI1-antibody associated epilepsy successfully treated in the outpatient setting,Journal of Neuroimmunology

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LGI1-antibody associated epilepsy successfully treated in the outpatient setting
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.jneuroim.2020.577268
R Uribe-San-Martín ₁ , E Ciampi ₁ , R Santibañez ₁ , S R Irani ₂ , A Márquez ₁ , J P Cruz ₃ , B Soler ₁ , M C Miranda ₁ , M Henríquez ₄ , C Cárcamo ₅

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We report six patients with anti-LGI1 associated epilepsy. Two patients presented with new-onset generalized tonic-clonic seizures, four developed faciobrachial dystonic seizures and two piloerection. All patients had significant cognitive complaints at the time of diagnosis. All patients described seizure reduction during the first week of carbamazepine, and seizure freedom was obtained at a median of 13 days (range 7–22), sustained after the initiation of immunosuppression. Median time from symptom onset to carbamazepine initiation was 164 days (range 38–206 days). We discuss the particular seizure response to sodium channel blocking antiepileptic drugs, alone or associated with immunosuppression in this antibody mediated seizures.

中文翻译：

LGI1 抗体相关性癫痫在门诊得到成功治疗

我们报告了 6 名患有抗 LGI1 相关性癫痫的患者。两名患者出现新发全身强直阵挛性癫痫发作，四名患者出现面臂肌张力障碍性癫痫发作，两名患者出现立毛。所有患者在诊断时都有明显的认知障碍。所有患者均描述卡马西平治疗第一周期间癫痫发作减少，中位 13 天（范围 7-22 天）癫痫发作消失，并在开始免疫抑制后持续。从症状出现到开始使用卡马西平的中位时间为 164 天（范围 38-206 天）。我们讨论了钠通道阻断抗癫痫药物单独或与抗体介导的免疫抑制相关的特殊癫痫发作反应。

更新日期：2020-08-01

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