BACKGROUND To explore the use of illicit drugs by people living with HIV (PLHIV) taking antiretroviral therapy (ART) and their relationship with variables relevant to the management of HIV infection, such as knowledge and beliefs about drug-drug interactions (DDIs), ART adherence, quality of life (QoL), and use of health-care resources. METHODS 21 PLHIV in Spain who concomitantly took illicit drugs and ART participated in this qualitative study. Eight experts collaborated in the design of the semi-structured interview guide which explored the following topics: illicit drug use, knowledge and beliefs about DDIs and their impact on ART adherence, the effects of using illicit drugs on health, QoL, and use of health-care resources. Four of those experts, who were PLHIV and members of the executive boards of non-government organizations (NGOs) from four Spanish regions, recruited the participants through their NGOs and carried out the face-to-face interviews. Content analysis of the qualitative data was conducted with the support of the MAXQDA 12 program. RESULTS Participants were mainly men (85.7%) and only 14.3% of them were heterosexual. Content analysis showed that the most frequently consumed illicit drugs were poppers, cocaine, and cannabis. Participants were polydrug users and this was, in many cases, prior to HIV diagnosis. Most participants presented theoretical potential moderate DDIs that would require monitoring. More than three quarters of them were not aware of these DDIs. Participants reported interactive toxicity beliefs that lead to intentional nonadherence behaviors. In most cases (n = 17), the participant's doctor knew about their drug use, however only six of them had had an open dialogue with their physician about it. Illicit drug use led to some health-related problems, mainly sexually transmitted infections. A positive QoL's self-perception was found among several participants that used recreational illicit drugs. CONCLUSIONS Adequate information about DDIs and clues about how to manage ART when PLHIV are using illicit drugs could reduce the negative effects of such interactions and improve ART adherence and QoL.

中文翻译：

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药物使用和抗逆转录病毒疗法（ART）的相互作用：一项定性研究，旨在探索服用ART和非法药物的HIV感染者的知识，信念，依从性和生活质量。

背景技术探讨服用抗逆转录病毒疗法（ART）的HIV感染者（PLHIV）的非法药物使用及其与与HIV感染管理相关的变量的关系，例如有关药物相互作用的知识和信念，ART依从性，生活质量（QoL）和医疗资源的使用。方法西班牙的21名艾滋病毒携带者同时服用非法药物和抗病毒药物参加了该定性研究。八位专家合作设计了半结构化访谈指南，该指南探讨了以下主题：非法药物的使用，对DDI的知识和信念及其对抗逆转录病毒依从性的影响，使用非法药物对健康，生活质量和健康使用的影响护理资源。其中四位专家 他们是PLHIV病毒，是西班牙四个地区的非政府组织（NGOs）执行委员会成员，通过其NGO招募了参与者，并进行了面对面的采访。在MAXQDA 12程序的支持下进行了定性数据的内容分析。结果参加者主要是男性（85.7％），其中只有14.3％是异性恋。含量分析表明，最经常消费的非法药物是波普尔，可卡因和大麻。参加者是多药使用者，在许多情况下，这是在艾滋病毒诊断之前。大多数参与者介绍了需要监控的理论上潜在的中等DDI。其中四分之三以上的人不知道这些DDI。参与者报告了相互作用的毒性信念，导致故意的不遵守行为。在大多数情况下（n = 17），参与者的医生知道他们的药物使用情况，但是只有六个人与他们的医生进行过公开对话。非法使用毒品导致一些与健康有关的问题，主要是性传播感染。在使用消遣性非法药物的几名参与者中发现了积极的生活质量自我感知。结论当PLHIV使用非法药物时，有关DDI的充分信息以及如何管理ART的线索可以减少此类相互作用的负面影响，并提高ART的依从性和QoL。在使用娱乐性非法药物的几名参与者中发现了自我感觉。结论当PLHIV使用非法药物时，有关DDI的足够信息以及如何管理ART的线索可以减少此类相互作用的负面影响，并提高ART的依从性和QoL。在使用娱乐性非法药物的几名参与者中发现了自我感觉。结论当PLHIV使用非法药物时，有关DDI的足够信息以及如何管理ART的线索可以减少此类相互作用的负面影响，并提高ART的依从性和QoL。