BACKGROUND Follicular lymphoma (FL) is characterized by frequent relapses and need for multitude lines of therapy, which includes different immunochemotherapy regimens, novel monoclonal antibodies, novel drugs, and autologous or allogenic stem cell transplant. Early use of autologous stem cell transplantation (ASCT) improves prognosis in patients with FL who may be candidates for an aggressive approach. CASE PRESENTATION We report the case of a 49-year-old woman with thrombophilia with relapsed/refractory grade 3A FL, heavily pretreated, who achieved third complete remission after high-dose chemotherapy and ASCT, despite experiencing life-threatening adverse events during her treatment history. CONCLUSIONS Stem cell transplantation has emerged as the standard of care for young patients with FL but may be effective also in complex and multirelapsed clinical cases.

中文翻译：

---

完成复杂和多复发滤泡性淋巴瘤的自体干细胞移植。

背景滤泡性淋巴瘤（FL）的特点是频繁复发，需要多种治疗方案，包括不同的免疫化疗方案、新型单克隆抗体、新型药物和自体或同种异体干细胞移植。早期使用自体干细胞移植 (ASCT) 可改善可能适合积极治疗的 FL 患者的预后。病例介绍 我们报告了一例患有血栓形成倾向的复发性/难治性 3A 级 FL 的病例，经过大量预处理，尽管在治疗期间经历了危及生命的不良事件，但在大剂量化疗和 ASCT 后实现了第三次完全缓解历史。