Background: Women diagnosed as having a high risk for breast cancer (HR-BC) often seek different health behaviors (HBs) such as complementary and alternative medicine (CAM), diet, and exercise to improve their health and cancer outcome. Methods: Women already enrolled in a multimodality screening study for patients at HR-BC (gene mutation carrier or >20% cumulative lifetime risk) were given a questionnaire to evaluate their use of CAM therapies, diet, and exercise before and after a diagnosis of HR-BC. Patients were also asked to complete the Short-Form 36, State-Trait Anxiety Inventory, and Beck Depression Inventory. Results: A total of 134 (67%) subjects completed the survey from the original cohort. General characteristics included a median age of 46 years (range = 24-73 years), majority were White (91%), BRCA1/2 gene mutation carrier (49%), and prior diagnosis of breast and/or ovarian cancer (30%). Almost all of the patients reported a lifetime prevalence of any HB (97%) and CAM utilization (91%). Subjects also had a high lifetime utilization of exercise (83%), herbs and supplements(72%), and diet programs (58%). All of these HBs declined in utilization after diagnosis of HR-BC by as much as 30%. After diagnosis of a HR-BC, a personal history of breast and/or ovarian cancer was significantly correlated with increased use of CAM (odds ratio [OR] = 5.9, P < .01), herbs and supplements (OR = 4.3, P < .01), and diet program (OR = 4.4, P < .01) in multivariate analysis. Conclusions: HBs such as CAM, diet, and exercise are highly prevalent among women with HR-BC, and the utilization of HB decreases significantly after diagnosis of HR-BC.

中文翻译：

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在患乳腺癌的高危女性中使用补充替代医学、饮食和运动。

背景：被诊断出患有乳腺癌 (HR-BC) 高风险的女性通常会寻求不同的健康行为 (HB)，例如补充和替代医学 (CAM)、饮食和锻炼，以改善她们的健康和癌症结果。方法：已参加一项针对 HR-BC 患者（基因突变携带者或 >20% 累积终生风险）的多模式筛查研究的女性接受了一份问卷，以评估她们在诊断为HR-BC。患者还被要求完成简表 36、状态-特质焦虑量表和贝克抑郁量表。结果：共有 134 (67%) 名受试者完成了原始队列的调查。一般特征包括中位年龄 46 岁（范围 = 24-73 岁），大多数是白人 (91%)，BRCA1/2 基因突变携带者 (49%)，和先前诊断为乳腺癌和/或卵巢癌 (30%)。几乎所有患者都报告了任何 HB (97%) 和 CAM 利用率 (91%) 的终生患病率。受试者在运动 (83%)、草药和补充剂 (72%) 以及饮食计划 (58%) 方面的终生利用率也很高。在诊断为 HR-BC 后，所有这些 HBs 的利用率都下降了 30%。诊断为 HR-BC 后，乳腺癌和/或卵巢癌的个人病史与 CAM（优势比 [OR] = 5.9，P < .01）、草药和补充剂（OR = 4.3，P < .01）和饮食计划（OR = 4.4，P < .01）在多变量分析中。结论： CAM、饮食和运动等 HBs 在 HR-BC 女性中非常普遍，并且在 HR-BC 诊断后 HB 的利用显着降低。