Age-related expression of SARS-CoV-2 priming protease TMPRSS2 in the developing lung.,bioRxiv - Developmental Biology

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Age-related expression of SARS-CoV-2 priming protease TMPRSS2 in the developing lung.
bioRxiv - Developmental Biology Pub Date : 2020-08-03 , DOI: 10.1101/2020.05.22.111187
Bryce A Schuler ₁ , A Christian Habermann ₂ , Erin J Plosa ₃ , Chase J Taylor ₂ , Christopher Jetter ₃ , Meghan E Kapp ₄ , John T Benjamin ₃ , Peter Gulleman ₃ , David S Nichols ₂ , Lior Z Braunstein ₅ , Alice Hackett ₁ , Michael Koval _{6,

7} , Susan H Guttentag ₃ , Timothy S Blackwell _{2,

8,

9} , , Steven A Webber ₁ , Nicholas E Banovich ₁₀ , Jonathan A Kropski _{2,

8,

9} , Jennifer M S Sucre _{3,

8} ,

Affiliation

The emergence of the SARS-CoV-2 novel coronavirus has led to a global pandemic (COVID-19), with more than 5 million cases as of May 2020. Available data suggest that severe illness and death from COVID-19 are rare in the pediatric population. Integrating single-cell RNA sequencing of the developing mouse lung with temporally-resolved RNA-in-situ hybridization (ISH) in mouse and human lung tissue, we found expression of SARS-CoV-2 Spike protein primer TMPRSS2 was highest in ciliated cells and type I alveolar epithelial cells (AT1) and increased with aging in mice and humans. SARS-CoV-2 RNA colocalized with TMPRSS2 mRNA in lung cells from a patient who died of SARS-CoV-2. Together, these data suggest developmental regulation of TMPRSS2 may underlie the relative protection of infants and children from severe respiratory illness.

更新日期：2020-08-04

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