How the intrinsic sequence structure of neonatal mouse pup ultrasonic vocalization (USV) and maternal experiences determine maternal behaviors in mice is poorly understood. Our previous work showed that pups with a Tbx1 heterozygous (HT) mutation, a genetic risk for autism spectrum disorder (ASD), emit altered call sequences that do not induce maternal approach behaviors in C57BL6/J mothers. Here, we tested how maternal approach behaviors induced by wild-type and HT USVs are influenced by the mother's experience in raising pups of these two genotypes. The results showed that wild-type USVs were effective in inducing maternal approach behaviors when mothers raised wild-type but not HT pups. The USVs of HT pups were ineffective regardless of whether mothers raised HT or wild-type pups. However, the sequence structure of pup USVs had no effect on the general, non-directional incentive motivation of maternal behaviors. Our data show how the mother's experience with a pup with a genetic risk for ASD alters the intrinsic incentive values of USV sequences in maternal approach behaviors.

中文翻译：

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母亲抚养带有自闭症风险基因变异的幼崽的经历会削弱孕产妇对待新生儿的行为

新生小鼠幼仔超声发声（USV）的固有序列结构和母体经验如何确定小鼠的母体行为知之甚少。我们以前的工作表明，具有Tbx1杂合（HT）突变（自闭症谱系障碍（ASD）的遗传风险）的幼犬发出改变的呼叫顺序，不会引起C57BL6 / J母亲的母体接近行为。在这里，我们测试了野生型和HT USV诱导的母体接近行为如何受到母亲养育这两种基因型幼崽的经验的影响。结果表明，当母亲抚养野生型而非HT幼崽时，野生型USV可以有效地诱导产妇接近行为。HT幼崽的USV无效，无论母亲是否饲养HT幼崽或野生型幼崽。然而，幼崽USV的序列结构对产妇行为的一般性，无方向性的激励动机没有影响。我们的数据表明母亲对有ASD遗传风险的幼崽的经历如何改变USV序列在母亲接近行为中的内在激励值。