Magnetic resonance imaging (MRI) studies report widespread cortical thinning in individuals with alcohol use disorder (AUD), but did not consider potential effects of pro-atherogenic conditions such as hypertension, type 2 diabetes mellitus, hepatitis C seropositivity and hyperlipidemia on cortical thickness. The conditions are associated with regional cortical thinning in those without AUD. We predicted that individuals with concurrent AUD and pro-atherogenic conditions demonstrate the greatest regional cortical thinning in areas most vulnerable to decreased perfusion.

中文翻译：

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与动脉粥样硬化有关的医疗状况与酒精使用障碍患者的皮质变薄有关。

磁共振成像 (MRI) 研究报告了酒精使用障碍 (AUD) 个体的广泛皮质变薄，但没有考虑促动脉粥样硬化疾病如高血压、2 型糖尿病、丙型肝炎血清阳性和高脂血症对皮质厚度的潜在影响。这些情况与那些没有 AUD 的人的区域皮质变薄有关。我们预测，同时患有 AUD 和促动脉粥样硬化病症的个体在最容易受到灌注减少影响的区域表现出最大的区域皮质变薄。