Cannabis sativa L. is an important yet controversial plant with a long history of recreational, medicinal, industrial, and agricultural use, and together with its sister genus Humulus, it represents a group of plants with a myriad of academic, agricultural, pharmaceutical, industrial, and social interests. We have performed a meta-analysis of pooled published genomics data, and we present a comprehensive literature review on the evolutionary history of Cannabis and Humulus, including medicinal and industrial applications. We demonstrate that current Cannabis genome assemblies are incomplete, with ∼10% missing, 10-25% unmapped, and 45S and 5S ribosomal DNA clusters as well as centromeres/satellite sequences not represented. These assemblies are also ordered at a low resolution, and their consensus quality clouds the accurate annotation of complete, partial, and pseudogenized gene copies. Considering the importance of genomics in the development of any crop, this analysis underlines the need for a coordinated effort to quantify the genetic and biochemical diversity of this species. Expected final online publication date for the Annual Review of Physical Chemistry, Volume 71 is April 20, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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大麻及其近亲的基因组学

Cannabis sativa L. 是一种重要但有争议的植物，具有悠久的娱乐、药用、工业和农业用途，与其姊妹属葎草一起代表了一组具有无数学术、农业、制药、工业用途的植物。 ，和社会利益。我们对已发表的汇总基因组数据进行了荟萃分析，并对大麻和葎草的进化历史进行了全面的文献综述，包括医药和工业应用。我们证明当前的大麻基因组组装是不完整的，约 10% 缺失，10-25% 未映射，45S 和 5S 核糖体 DNA 簇以​​及着丝粒/卫星序列未显示。这些程序集也以低分辨率排序，它们的一致性质量掩盖了完整、部分和假基因拷贝。考虑到基因组学在任何作物发育中的重要性，该分析强调需要协调一致地量化该物种的遗传和生化多样性。《物理化学年度评论》第 71 卷的预计最终在线出版日期为 2020 年 4 月 20 日。请参阅 http://www.annualreviews.org/page/journal/pubdates 了解修订后的估计值。