ABSTRACT

Long noncoding RNAs (lncRNAs) have been found to associate with all major types of malignancies and play important roles in regulating several hallmarks of cancer by interacting with proteins, DNA, and RNA. The possible functions of lncRNAs and their roles in the regulation of tumour growth will be reported and discussed in the present review. In our recent report, based on genetic mice models and a series of systematic analyses, we suggested that lncRNAs also play critical roles in the regulation of antigen presentation in tumour cells and allow tumour cells to escape immune surveillance, which further broadens the scope of understanding lncRNA functions and how they relate to cancer immunotherapy resistance.

 抽象的

长非编码 RNA (lncRNA) 已被发现与所有主要类型的恶性肿瘤相关，并通过与蛋白质、DNA 和 RNA 相互作用，在调节癌症的多种特征中发挥重要作用。本综述将报道和讨论 lncRNA 的可能功能及其在肿瘤生长调节中的作用。在我们最近的报告中，基于遗传小鼠模型和一系列系统分析，我们提出lncRNA在肿瘤细胞抗原呈递的调节中也发挥着关键作用，并使肿瘤细胞能够逃避免疫监视，这进一步拓宽了我们的认识范围lncRNA 功能及其与癌症免疫治疗耐药性的关系。