γδ T cells have recently gained considerable attention as an attractive tool for cancer adoptive immunotherapy due to their potent anti-tumor activity and unique role in immunosurveillance. The remarkable success of engineered T cells for the treatment of hematological malignancies has revolutionized the field of adoptive cell immunotherapy. Accordingly, major efforts are underway to translate this exciting technology to the treatment of solid tumors and the development of allogeneic therapies. The unique features of γδ T cells, including their major histocompatibility complex (MHC)-independent anti-cancer activity, tissue tropism, and multivalent response against a broad spectrum of the tumors, render them ideal for designing universal ‘third-party’ cell products, with the potential to overcome the challenges of allogeneic cell therapy. In this review, we describe the crucial role of γδ T cells in anti-tumor immunosurveillance and we summarize the different approaches used for the ex vivo and in vivo expansion of γδ T cells suitable for the development of novel strategies for cancer therapy. We further discuss the different transduction strategies aiming at redirecting or improving the function of γδ T cells, as well as, the considerations for the clinical applications.

中文翻译：

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γδ T 细胞：癌症免疫治疗的理想工具。


由于其强大的抗肿瘤活性和在免疫监视中的独特作用，γδ T 细胞作为癌症过继性免疫治疗的有吸引力的工具，最近受到了相当大的关注。工程化 T 细胞在治疗血液恶性肿瘤方面取得的巨大成功彻底改变了过继性细胞免疫疗法领域。因此，人们正在努力将这项令人兴奋的技术转化为实体瘤的治疗和同种异体疗法的开发。 γδ T 细胞的独特特征，包括其主要组织相容性复合体 (MHC) 独立的抗癌活性、组织向性和针对广谱肿瘤的多价反应，使它们成为设计通用“第三方”细胞产品的理想选择，有潜力克服同种异体细胞疗法的挑战。在这篇综述中，我们描述了 γδ T 细胞在抗肿瘤免疫监视中的关键作用，并总结了用于离体和体内扩增 γδ T 细胞的不同方法，适用于开发新的癌症治疗策略。我们进一步讨论了旨在重定向或改善γδ T细胞功能的不同转导策略，以及临床应用的考虑因素。