PDEGMA‐b‐PDIPAEMA copolymers via RAFT polymerization and their pH and thermoresponsive schizophrenic self‐assembly in aqueous media,Journal of Polymer Science

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PDEGMA‐b‐PDIPAEMA copolymers via RAFT polymerization and their pH and thermoresponsive schizophrenic self‐assembly in aqueous media
Journal of Polymer Science ( IF 3.9 ) Pub Date : 2020-05-23 , DOI: 10.1002/pol.20200266
Dimitrios Selianitis ₁ , Stergios Pispas ₁

Affiliation

We report on a new doubly responsive polymeric system of amphiphilic diblock copolymers, namely poly(di‐[ethylene glycol] methyl ether methacrylate)‐b‐poly(2‐[diisopropylamino] ethyl methacrylate), PDEGMA‐b‐PDIPAEMA, obtained by the reversible addition‐fragmentation chain transfer (RAFT) polymerization technique. Molecular characterization by size exclusion chromatography (SEC), nuclearmagnetic resonance (¹H‐NMR) and infrared spectroscopy (FT‐IR) confirms the successful synthesis of these novel block copolymers. The PDEGMA‐b‐PDIPAEMA block copolymers formed aggregates in aqueous media in response to solution pH and temperature changes, as evidenced by dynamic and static light scattering techniques, as well as fluorescence spectroscopy. Aggregates with PDEGMA core and PDIPAEMA corona domains are formed at elevated temperatures and low pH, whereas aggregates with PDIPAEMA cores and PDEGMA coronas are formed at neutral and high pH. Overall structural characteristics and solution behavior of the copolymers are affected by the copolymer composition. The obtained results provide valuable new information on the behavior and design guidelines for the construction of stimuli responsive, “schizophrenic” polymeric nanostructures with potential application in the biomedical field.

中文翻译：

PDEGMA-b-PDIPAEMA共聚物通过RAFT聚合及其在水性介质中的pH和热响应性精神分裂症自组装

我们报告了一种新的两亲性二嵌段共聚物的双响应聚合物体系，即聚（二[乙二醇]甲基醚甲基丙烯酸甲酯）-b-聚（2- [二异丙基氨基]甲基丙烯酸乙酯）PDEGMA-b-PDIPAEMA，由可逆加成-断裂链转移（RAFT）聚合技术。通过尺寸排阻色谱法（SEC），核磁共振进行分子表征（¹H-NMR）和红外光谱（FT-IR）证实了这些新型嵌段共聚物的成功合成。PDEGMA-b-PDIPAEMA嵌段共聚物在水溶液中响应溶液的pH和温度变化而形成聚集体，这通过动态和静态光散射技术以及荧光光谱法得以证明。具有PDEGMA核心和PDIPMAEMA电晕域的聚集体在高温和低pH下形成，而具有PDIPAEMA核心和PDEGMA电晕域的聚集体在中性和高pH下形成。共聚物的整体结构特征和溶液行为受共聚物组成的影响。获得的结果提供了有关行为和设计准则的有价值的新信息，用于构建刺激响应，

更新日期：2020-05-23

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