Protective Effects of Antioxidant Polyphenols against Hyperglycemia-Mediated Alterations in Cerebral Endothelial Cells and a Mouse Stroke Model.,Molecular Nutrition & Food Research

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Protective Effects of Antioxidant Polyphenols against Hyperglycemia-Mediated Alterations in Cerebral Endothelial Cells and a Mouse Stroke Model.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-06-16 , DOI: 10.1002/mnfr.201900779
Angélique Arcambal ₁ , Janice Taïlé ₁ , David Couret _{1,

2} , Cynthia Planesse ₁ , Bryan Veeren ₁ , Nicolas Diotel ₁ , Anne Gauvin-Bialecki ₃ , Olivier Meilhac _{1,

2} , Marie-Paule Gonthier ₁

Affiliation

Hyperglycemia alters cerebral endothelial cell and blood‐brain barrier functions, aggravating cerebrovascular complications such as stroke during diabetes. Redox and inflammatory changes play a causal role. This study evaluates polyphenol protective effects in cerebral endothelial cells and a mouse stroke model during hyperglycemia.

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