Voltage‐gated sodium channels (NavChs) are biological pores that control the flow of sodium ions through the cell membrane. In humans, mutations in genes encoding NavChs can disrupt physiological cellular activity thus leading to a wide spectrum of diseases. Here, we present a topological connection between the functional architecture of a NavAb bacterial channel and accumulation of atomic hydropathicity around its pore. This connection is established via a scaling analysis methodology that elucidates how intrachannel hydropathic density variations translate into hydropathic dipole field configurations along the pore. Our findings suggest the existence of a nonrandom cumulative hydropathic topology that is organized parallel to the membrane surface so that pore's stability, as well as, gating behavior are guaranteed. Given the biophysical significance of the hydropathic effect, our study seeks to provide a computational framework for studying cumulative hydropathic topological properties of NavChs and pore‐forming proteins in general.

中文翻译：

---

电压门控钠通道在原子分辨率下的累积亲水拓扑。

电压门控钠通道（NavChs）是控制钠离子通过细胞膜流动的生物孔。在人类中，编码NavChs的基因突变会破坏生理细胞活性，从而导致多种疾病。在这里，我们介绍了NavAb细菌通道的功能结构与其孔周围原子亲水性的积累之间的拓扑联系。通过比例分析方法建立了这种联系，该方法阐明了通道内亲水密度变化如何沿孔隙转化为亲水偶极场构型。我们的发现表明，存在与膜表面平行组织的非随机累积亲水拓扑，因此可以确保孔的稳定性以及门控行为。