Hand‐arm vibration syndrome (HAVS) is an irreversible neurodegenerative, vasospastic, and musculoskeletal occupational disease of workers who use powered hand tools. The etiology is poorly understood. Neurological symptoms include numbness, tingling, and pain. This study examines impact hammer vibration‐induced injury and recoverability of hair mechanosensory innervation. Rat tails were vibrated 12 min/d for 5 weeks followed by 5 week recovery with synchronous non‐vibrated controls. Nerve fibers were PGP9.5 immunostained. Lanceolate complex innervation was compared quantitatively in vibrated vs sham. Vibration peak acceleration magnitudes were characterized by frequency power spectral analysis. Average magnitude (2515 m/s², root mean squared) in kHz frequencies was 109 times that (23 m/s²) in low Hz. Percentage of hairs innervated by lanceolate complexes was 69.1% in 5‐week sham and 53.4% in 5‐week vibration generating a denervation difference of 15.7% higher in vibration. Hair innervation was 76.9% in 5‐weeks recovery sham and 62.0% in 5‐week recovery vibration producing a denervation difference 14.9% higher in recovery vibration. Lanceolate number per complex (18.4 ± 0.2) after vibration remained near sham (19.3 ± 0.3), but 44.9% of lanceolate complexes were abnormal in 5 weeks vibrated compared to 18.8% in sham. The largest vibration energies are peak kHz accelerations (approximately 100 000 m/s²) from shock waves. The existing ISO 5349‐1 standard excludes kHz vibrations, seriously underestimating vibration injury risk. The present study validates the rat tail, impact hammer vibration as a model for investigating irreversible nerve damage. Persistence of higher denervation difference after 5‐week recovery suggests repeated vibration injury destroys the capability of lanceolate nerve endings to regenerate.

中文翻译：

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铆锤振动会损害机械感觉神经末梢。

手臂振动综合征 (HAVS) 是使用电动手动工具的工人的一种不可逆的神经退行性、血管痉挛和肌肉骨骼职业病。病因了解甚少。神经系统症状包括麻木、刺痛和疼痛。这项研究检查了冲击锤振动引起的损伤和头发机械感觉神经支配的可恢复性。大鼠尾巴以 12 分钟/天的频率振动 5 周，然后用同步非振动对照进行 5 周恢复。神经纤维被 PGP9.5 免疫染色。在振动与假手术中定量比较了披针形复合体的神经支配。振动峰值加速度幅度通过频率功率谱分析来表征。kHz 频率的平均震级（2515 m/s ²，均方根）是（23 m/s ²) 在低赫兹。由披针形复合物支配的毛发百分比在 5 周假手术中为 69.1%，在 5 周振动中为 53.4%，产生的去神经支配差异在振动中高出 15.7%。在 5 周恢复假手术中，头发神经支配率为 76.9%，在 5 周恢复振动中为 62.0%，在恢复振动中产生的去神经支配差异高出 14.9%。振动后每个复合物的披针形数量 (18.4 ± 0.2) 保持在假手术附近 (19.3 ± 0.3)，但 44.9% 的披针形复合物在振动 5 周后异常，而假手术中为 18.8%。最大的振动能量是峰值 kHz 加速度（大约 100 000 m/s ²) 来自冲击波。现有的 ISO 5349-1 标准不包括 kHz 振动，严重低估了振动伤害风险。本研究验证了鼠尾、冲击锤振动作为研究不可逆神经损伤的模型。5 周恢复后持续较高的去神经支配差异表明反复振动损伤破坏了披针形神经末梢的再生能力。