As an evolutionarily conserved pathway, Hippo signaling pathway impacts different pathology and physiology processes such as wound healing, tissue repair/size and regeneration. When some components of Hippo signaling dysregulated, it affects cancer cells proliferation. Moreover, the relation Hippo pathway with other signaling including Wnt, TGFβ, Notch, and EGFR signaling leaves effect on the proliferation of cancer cells. Utilizing a number of therapeutic approaches, such as siRNAs and long noncoding RNA (lncRNA) to prevent cancer cells through the targeting of Hippo pathways, can provide new insights into cancer target therapy. The purpose of present review, first of all, is to demonstrate the importance of Hippo signaling and its relation with other signaling pathways in cancer. It also tries to demonstrate targeting Hippo signaling progress in cancer therapy.

中文翻译：

---

对实体瘤生物学中核心 Hippo 信号传导和生物大分子相互作用的新见解。

作为进化上保守的通路，Hippo 信号通路影响不同的病理和生理过程，如伤口愈合、组织修复/大小和再生。当 Hippo 信号的某些成分失调时，它会影响癌细胞增殖。此外，Hippo 通路与其他信号包括 Wnt、TGFβ、Notch 和 EGFR 信号的关系对癌细胞的增殖产生影响。利用多种治疗方法，例如 siRNA 和长链非编码 RNA (lncRNA)，通过靶向 Hippo 通路来预防癌细胞，可以为癌症靶向治疗提供新的见解。本综述的目的首先是证明 Hippo 信号传导的重要性及其与癌症中其他信号传导途径的关系。