This study used contrast-enhanced ultrasound (CEUS) to evaluate changes in renal cortical blood perfusion after percutaneous transluminal renal angioplasty and stenting (PTRAS) for severe renal artery stenosis (RAS) (≥70%). CEUS was performed in 21 patients with 24 severe RASs that underwent PTRAS. Renal cortical perfusion was quantitatively evaluated by comparing time intensity curve (TIC) parameters for SonoVue (Bracco, Milan, Italy) contrast enhancement, including peak intensity (PI), time to peak (TTP), mean transmit time (MTT), curve ascending slope (S), area under the curve (AUC), AUC-wash-in and AUC-wash-out. The parameters PI, TTP, MTT and S differed significantly between the pre-intervention and post-intervention TIC analysis (p < 0.05). Of the 24 pre-intervention curve appearances, 58.3% (14/24) improved after operation. The PI difference correlated positively with the estimated glomerular filtration rate difference (r = 0.433, p < 0.05). In conclusion, changes in some ultrasound perfusion parameters on CEUS and the shape of the TIC can be used to quantitatively and intuitively evaluate renal cortical blood perfusion change after PTRAS.

本研究使用对比增强超声 (CEUS) 评估严重肾动脉狭窄 (RAS) (≥70%) 经皮腔内肾血管成形术和支架置入术 (PTRAS) 后肾皮质血液灌注的变化。对 21 名接受 PTRAS 的 24 名严重 RAS 患者进行了 CEUS。通过比较 SonoVue (Bracco, Milan, Italy) 对比增强的时间强度曲线 (TIC) 参数，包括峰值强度 (PI)、峰值时间 (TTP)、平均传输时间 (MTT)、曲线上升，定量评估肾皮质灌注斜率 (S)、曲线下面积 (AUC)、AUC 洗入和 AUC 洗出。PI、TTP、MTT 和 S 参数在干预前和干预后 TIC 分析之间存在显着差异（p< 0.05)。在 24 次干预前曲线出现中，58.3% (14/24) 术后改善。PI 差异与估计的肾小球滤过率差异呈正相关（r = 0.433，p < 0.05）。总之，CEUS 上一些超声灌注参数的变化和 TIC 的形状可用于定量和直观地评估 PTRAS 后肾皮质血液灌注变化。