Centrioles organize the microtubule network and mitotic spindle and, as basal bodies, nucleate cilia and flagella. They undergo a beguiling process in which one appears to give rise to another and at a baffling orthogonal geometry. Nucleic acid-based replication has been pondered during cycles of zeniths and nadirs of plausibility, the latter now the state. Centrioles can also arise de novo, and thus the longstanding focus on centriole ‘replication’ may have led us astray from ground truth. We are in an era in which the assembly pathways of most intracellular machines are becoming understood in considerable detail. But apart from knowing the structure and parts list, little in our extant knowledge conveys how centrioles arise. Here the matters at hand are summarized, and a siren call is sounded.

质心组织微管网络和有丝分裂纺锤体，以及作为基体的有核纤毛和鞭毛。它们经历了一个令人迷惑的过程，在这个过程中，一个人似乎产生了另一个，并以令人困惑的正交几何形状出现。在天顶和最低点的循环期间已经考虑了基于核酸的复制，后者现在处于状态。重心也可能从头出现，因此长期以来对重心“复制”的关注可能使我们偏离了地面真理。我们正处于一个时代，在这个时代，大多数细胞内机器的组装途径都变得越来越详细。但是，除了了解结构和零件清单之外，在我们现有的知识中，几乎没有传达出中心粒是如何产生的。这里总结了眼前的事情，并发出警笛声。