α-fetoprotein (AFP) as a target marker refers to albuminoid proteins, which is a tumor-related fetal protein, increasing the AFP concentration leads to various diseases, including liver cancer. Therefore, it is essential to develop fast, ultrasensitive and selective methods for early detection at trace levels. Several biosensing platforms have been developed concerning this purpose. The novel optical biosensors is developing as one of the most effective methods. The visibility of the target marker without employing any costly tools makes optical detection better than other methods. So, this review throws light on the role of this novel biosensors to the early detection of AFP, which is important in cancer diagnoses.

作为目标标记的甲胎蛋白（AFP）是指类白蛋白蛋白，它是一种与肿瘤相关的胎儿蛋白，AFP浓度升高会导致各种疾病，包括肝癌。因此，必须开发快速，超灵敏和选择性的方法，以痕量水平进行早期检测。为此目的，已经开发了几种生物传感平台。新型光学生物传感器正在发展成为最有效的方法之一。无需使用任何昂贵工具的目标标记的可见性使光学检测比其他方法更好。因此，本综述阐明了这种新型生物传感器在AFP的早期检测中的作用，这在癌症诊断中很重要。