Organisms belonging to the Family Chlamydiaceae are responsible for a broad range of diseases in humans, livestock, companion animals and non-domestic species. Infection of the reproductive organs can cause a range of syndromes of which sub- and infertility are the most frequently observed clinical manifestations. While the gross and histological lesions associated with the isolation of Chlamydiaceae from the non-human female reproductive tract are well documented, little attention has been given to the pathological effects of this infection in the male genital system. As such, the occurrence and importance of Chlamydia-associated disease in male non-human mammalian species is less well documented. In order to improve our understanding of the significance of chlamydiosis in domestic, laboratory and wild animals, this review provides an up-to-date summary of Chlamydia-associated male reproductive pathology, whether that infection occurs naturally or experimentally. Although most lesions in males are described as incidental and of minor significance, results of recent studies suggest that infection with Chlamydiaceae can adversely impact male fertility and/or be instrumental in disease transmission. Although in humans, bulls and mice Chlamydia infection has been associated with morphological and functional abnormalities of the spermatozoa, this review will focus on the gross and histological findings linked to the colonisation of the genital system by this pathogen. Advances in our understanding of male reproductive chlamydiosis are necessary for diagnostic and therapeutic strategies, as well as epidemiological and conservation studies.

中文翻译：

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非人类哺乳动物雄性生殖道衣原体病的发生和病理学：综述


属于衣原体科的生物体导致人类、牲畜、伴侣动物和非家养物种的多种疾病。生殖器官感染可引起一系列综合征，其中最常见的临床表现是不孕不育。虽然与从非人类女性生殖道中分离衣原体相关的肉眼和组织学损伤已有充分记录，但很少有人关注这种感染对男性生殖系统的病理影响。因此，雄性非人类哺乳动物物种中衣原体相关疾病的发生和重要性尚不清楚。为了提高我们对衣原体病在家养、实验室和野生动物中的重要性的理解，这篇综述提供了衣原体相关的男性生殖病理学的最新总结，无论这种感染是自然发生的还是实验发生的。尽管大多数男性病变被描述为偶然且意义不大，但最近的研究结果表明，衣原体感染会对男性生育能力产生不利影响和/或有助于疾病传播。尽管在人类、公牛和小鼠中，衣原体感染与精子的形态和功能异常有关，但本综述将重点关注与该病原体在生殖系统定植相关的总体和组织学发现。我们对男性生殖衣原体病的了解的进展对于诊断和治疗策略以及流行病学和保护研究是必要的。