Adipose tissue inflammation has been proposed as a central mechanism connecting obesity with its metabolic and vascular complications due to the imbalance in the expression of several hormones and adipokines. Berries rich in polyphenols and unsaturated fatty acids have been able to prevent both obesity and adipose tissue inflammation, improving metabolic functions in human subjects and animal models of obesity. Juçara has been considered a super fruit owing to its nutritional composition and relevant biological activities with an interesting response in animals. Thus, we aimed to verify the potential antiobesogenic effect of juçara supplementation in humans. We conducted a double-blind, placebo-controlled, randomized trial with 35 adults with obesity of both sexes. They were assessed for resting metabolic rate, anthropometry and body composition, blood pressure, metabolic parameters and adipokines. Subsequently, they were randomized into two groups to use or not (placebo) 5 g lyophilized juçara for 6 weeks. Supplementation with juçara was significantly effective in reducing body fat, increasing high-density lipoprotein cholesterol and doubling serum adiponectin. Besides, juçara supplementation, high-density lipoprotein cholesterol and neck circumference were predictors to explain the enhancement in adiponectin. Juçara supplementation was determinant to improve adiponectin levels, and it may be considered a novel strategy for the treatment of obesity-related metabolic diseases.

由于几种激素和脂肪因子的表达失衡，已提出将脂肪组织炎症作为连接肥胖与其代谢和血管并发症的主要机制。富含多酚和不饱和脂肪酸的浆果已经能够预防肥胖和脂肪组织发炎，改善人类对象和肥胖动物模型的代谢功能。Juçara因其营养成分和相关的生物活性而被认为是超级水果，并在动物中引起有趣的反应。因此，我们旨在验证jujua补充剂对人体的潜在抗肥胖作用。我们对35位男女肥胖的成年人进行了一项双盲，安慰剂对照的随机试验。对他们进行了静息代谢率，人体测量学和身体成分的评估，血压，代谢参数和脂肪因子。随后，将他们随机分为两组，使用或不使用（安慰剂）5 g冻干juçara，持续6周。添加juçara可以有效减少体内脂肪，增加高密度脂蛋白胆固醇，并使血清脂联素增加一倍。此外，jujuara补充剂，高密度脂蛋白胆固醇和颈围是解释脂联素增强的预测因子。Juçara补充剂是决定脂联素水平提高的决定因素，它可能被认为是治疗与肥胖相关的代谢性疾病的新策略。添加juçara可以有效减少体内脂肪，增加高密度脂蛋白胆固醇，并使血清脂联素增加一倍。此外，jujuara补充剂，高密度脂蛋白胆固醇和颈围是解释脂联素增强的预测因子。Juçara补充剂是决定脂联素水平提高的决定因素，它可能被认为是治疗与肥胖相关的代谢性疾病的新策略。添加juçara可以有效减少体内脂肪，增加高密度脂蛋白胆固醇，并使血清脂联素增加一倍。此外，jujuara补充剂，高密度脂蛋白胆固醇和颈围是解释脂联素增强的预测因子。Juçara补充剂是决定脂联素水平提高的决定因素，它可能被认为是治疗与肥胖相关的代谢性疾病的新策略。