The present study was undertaken to develop an animal model to study neurolathyrism. For this purpose 24 goat (Capra hircus) kids (new born, 15 days old) were divided into four groups. Group I Control, Group II Low toxin (0.17 g% β-ODAP containing grass pea), Group III high toxin (0.96 g% β-ODAP containing grass pea) and Group IV high toxin (0.96 g% β-ODAP containing grass pea flour (powder) fortified with 5 mg% pure β-ODAP). The experiment was continued for 3 months. Clinical examination was carried out weekly. Muscle conduction velocity (MCV), nerve conduction velocity (NCV), blood and urinary β-ODAP, nitrite in blood and cerebrospinal fluid (CSF) examination were performed by standard methods. Clinical examination showed neurolathyrism symptoms in three kids. The abnormal MCV and NCV were observed in all the experimental animals. Blood nitrite, blood and urine β-ODAP levels were significantly increased in experimental groups. Three kids were affected with neurolathyrism due to consumption of grass pea irrespective of its β-ODAP content and kid may serve as a neurolathyrism model.

进行本研究以开发用于研究神经neuro症的动物模型。为此目的，24山羊（Capra hircus）孩子（新生，15天大）分为四组。I组对照组，II组低毒素（0.17 g％含草豌豆的β-ODAP），III组高毒素（0.96 g％含草豌豆的β-ODAP）和IV组高毒素（0.96 g％的含草豌豆的β-ODAP）面粉（粉）中加入5 mg％的纯β-ODAP）。实验持续了3个月。每周进行一次临床检查。肌肉传导速度（MCV），神经传导速度（NCV），血液和尿液β-ODAP，血液中的亚硝酸盐和脑脊液（CSF）的检查均采用标准方法。临床检查显示三个孩子出现神经la症症状。在所有实验动物中均观察到异常的MCV和NCV。实验组的血液亚硝酸盐，血液和尿液中的β-ODAP水平显着升高。