Mitochondria is a key cellular organelle, which is tightly supervised by multiple oversight cellular mechanisms regulating mitochondrial biogenesis and mitochondria maintenance and/or elimination. Selective autophagy of mitochondria, id est mitophagy, is one of the cellular mechanisms controlling mitochondria homeostasis. The nematode Caenorhabditis elegans has recently emerged as a powerful model organism to study the roles and functions of mitophagy. We present here the current knowledge on cellular and molecular mechanisms underlying the selective elimination of mitochondria by autophagy in C. elegans in the context of developmental processes, aging and adaptive responses to various stresses.

线粒体是关键的细胞器，它由调节线粒体生物发生和线粒体维持和/或消除的多种监督细胞机制严格监管。线粒体的选择性自噬，ID EST自噬，是控制线粒体内稳态相关的细胞机制之一。线虫秀丽隐杆线虫最近已经成为研究线粒体的作用和功能的强大模型生物。我们在这里提出线粒体中选择性消除由自噬在底层细胞和分子机制的当前知识线虫在发育过程的上下文中，老化和对各种胁迫的适应性反应。