Abstract Magnetic photonic crystals are an emerging class of responsive colloidal systems with unique variable optical properties. This article is dedicated to the first example of polyelectrolyte-based magnetic photonic crystals produced by layer-by-layer adsorption of polymeric molecules onto magnetite cores. Proper selection of the polycationic and polyanionic molecules allowed to produce a stable colloidal system composed of monodisperse nanoaggregates with a mean diameter of 180 nm. In the presence of weak magnetic fields up to 650 G, the reflectance spectra of the colloid system showed a blue shift, changing spectra peak maximum from 720 to 445 nm. Mild synthetic conditions allowed to use natural polymers, such as heparin, expanding the bioactivity of the produced material. Magnetic photonic crystals have demonstrated excellent biocompatibility with minor cytotoxicity on HeLa cell line up to 200 μg/mL concentration, and anticoagulant activity comparable to free heparin. The synthesized material can find its application in the fields of optics, biosensorics, or biocompatible magnetic drug delivery systems for anticoagulant therapy.

中文翻译：

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具有抗凝活性的聚电解质基磁性光子晶体

摘要 磁性光子晶体是一类新兴的响应胶体系统，具有独特的可变光学特性。本文致力于通过将聚合物分子逐层吸附到磁铁矿芯上而产生的基于聚电解质的磁性光子晶体的第一个例子。正确选择聚阳离子和聚阴离子分子可以产生由平均直径为 180 nm 的单分散纳米聚集体组成的稳定胶体系统。在高达 650 G 的弱磁场存在下，胶体系统的反射光谱显示蓝移，将光谱峰值从 720 更改为 445 nm。温和的合成条件允许使用天然聚合物，如肝素，扩大生产材料的生物活性。磁性光子晶体显示出优异的生物相容性，对浓度高达 200 μg/mL 的 HeLa 细胞系的细胞毒性很小，抗凝活性与游离肝素相当。合成的材料可以在光学、生物传感或用于抗凝治疗的生物相容性磁性药物递送系统领域中得到应用。