Purpose

: Lettuce has demonstrated antidiabetic, antioxidant and anti-inflammatory activities. In the present work the hypolipidemic effect of chronic administration of aqueous-ethanolic extract of lettuce (Lactuca sativa) seed was investigated. Hyperlipidemic patients meeting the inclusion criteria were randomly assigned into the treatment and placebo groups.

Methods

: All patients received atorvastatin (20 mg/day) as the main drug. The patients in treatment group took lettuce seed capsule (1000 mg, once per day); whereas the patients in placebo group took placebo capsule (once per day) for 12 weeks. The lipid profile, blood pressure, body mass index and liver enzymes of the patients were evaluated at baseline, and after 6 and 12 weeks of the clinical trial.

Result and conclusion

: The results indicated that lettuce seed extract significantly (P < 0.05) improved triglyceride, cholesterol, Low-Density Lipoprotein (LDL) and High-Density Lipoprotein (HDL) compared to the placebo group. It had no effect on systolic or diastolic blood pressure and the effect on BMI reduction was not significant (P > 0.05) compared to placebo. The lettuce seed extract showed an inhibitory effect on atorvastatin-induced elevation of hepatic enzymes and possible liver toxicity. No serious side effect was reported for lettuce seed extract administration. Therefore, lettuce seed extract could be considered as a supplement for treatment of dyslipidemia.

中文翻译：

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辅助治疗对高脂血症患者的紫草种子提取物的降血脂作用：一项随机双盲安慰剂对照试验

目的

：生菜具有抗糖尿病，抗氧化和抗炎的作用。在目前的工作莴苣的水-乙醇提取物的长期施用的降血脂作用（莴）种子进行了研究。符合纳入标准的高脂血症患者被随机分为治疗组和安慰剂组。

方法

：所有患者均接受阿托伐他汀（20毫克/天）作为主要药物。治疗组患者服用生菜种子胶囊（1000 mg，每天一次）。安慰剂组患者服用安慰剂胶囊（每天一次），持续12周。在基线时以及临床试验的6周和12周后，评估了患者的血脂，血压，体重指数和肝酶。

结果与结论

：结果表明，与安慰剂组相比，生菜种子提取物显着改善（P <0.05）甘油三酸酯，胆固醇，低密度脂蛋白（LDL）和高密度脂蛋白（HDL）。与安慰剂相比，它对收缩压或舒张压没有影响，对BMI降低的影响不显着（P> 0.05）。生菜种子提取物对阿托伐他汀诱导的肝酶升高和可能的肝毒性有抑制作用。对于生菜种子提取物的施用，没有严重的副作用的报道。因此，莴苣种子提取物可以被认为是治疗血脂异常的补充。