Ribozymes with modular structures are attractive platforms for the construction of nanoscale RNA objects with biological functions. We designed group I ribozyme dimers as unit ribozyme dimers (Urds), which self-assembled to form their polymeric states and also oligomeric states with defined numbers of Urds. Assembly of Urds yielded catalytic ability of a pair of distinct ribozyme units to cleave two distinct substrates. The morphologies of the assembled ribozyme structures were observed directly by atomic force microscopy (AFM).

中文翻译：

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通过I组核酶二聚体自组装形成的催化RNA纳米物体，作为单元结构。

具有模块化结构的核酶是构建具有生物学功能的纳米级RNA物体的诱人平台。我们将I组核酶二聚体设计为单位核酶二聚体（Urds），该单元自组装形成其聚合态以及具有限定数量的Urds的寡聚态。Urds的组装产生了一对不同的核酶单位的催化能力，可裂解两种不同的底物。组装的核酶结构的形态直接通过原子力显微镜（AFM）观察。