The question of whether some cases of interstitial cystitis may have an infectious etiology has been debated for some time. Previous studies have looked for the presence of certain specific viruses, but generally did not use the types of sensitive and unbiased approaches that are currently available. As part of the MAPP (Multidisciplinary Approach to the Study of Chronic Pelvic Pain) Research Network, we examined urine specimens from interstitial cystitis patients who provided specimens over time and also reported various symptoms at the time of urine collection. We first performed next-generation sequencing to look for the presence of viruses in urines, and detected two human polyomaviruses that are known to be excreted into urine, BKPyV and JCPyV. We were especially interested in BKPyV because it is a known cause of another bladder disease, hemorrhagic cystitis, in bone marrow transplant recipients. Further analysis of individual samples indicates a trend toward higher excretion of polyomaviruses in patients experiencing increased symptoms.

中文翻译：

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分析间质性膀胱炎患者尿液中存在的病毒。

一些间质性膀胱炎病例是否可能具有感染性病因的问题已经争论了一段时间。以前的研究一直在寻找某些特定病毒的存在，但通常没有使用目前可用的敏感和无偏见的方法类型。作为 MAPP（慢性盆腔疼痛研究的多学科方法）研究网络的一部分，我们检查了间质性膀胱炎患者的尿液样本，这些患者随时间推移提供了样本，并在收集尿液时报告了各种症状。我们首先进行了二代测序以寻找尿液中是否存在病毒，并检测到两种已知会排泄到尿液中的人类多瘤病毒 BKPyV 和 JCPyV。我们对 BKPyV 特别感兴趣，因为它是另一种膀胱疾病的已知原因，骨髓移植受者的出血性膀胱炎。对个体样本的进一步分析表明，在症状加重的患者中，多瘤病毒有更高的排泄趋势。