Despite recent advances in tumor treatment, reactive oxygen species (ROS)-mediated therapy, such as photodynamic therapy (PDT) and chemical dynamic therapy (CDT), remains challenging mainly due to hypoxia in tumor microenviroment. Relieving the hypoxia of tumor tissue has been considered as an attractive strategy for enhancing efficacy of ROS-based cancer treatment. Herein, one cascaded platform was developed to overcome tumor hypoxia and synergistically enhance the effect of ROSmediated therapy. This platform is based on cleavable bimetallic metal organic polymers (DOX@Fe/Mn-THPP_TK-PEG). As an efficient Fenton-like material, it could not only produce cytotoxic •OH by catalyzing the decomposition of intracellular H₂O₂, but also generate O₂ to alleviate tumor hypoxia. In addition, the DOX-loaded metal organic polymers (MOPs could be disrupted after being exposed to laser irradiation or/and treated with H₂O₂, and then release the DOX for chemotherapy. Overall, 3 therapies (hypoxia-relieved PDT, photo-enhanced CDT, and ROS-mediated chemotherapy) could be achieved simultaneously by such a smart platform. Furthermore, T₁-weighted MRI imaging ability of the MOPs could be greatly improved under H₂O₂ treatment. Therefore, total four robust functions were realized in a simple platform. These findings demonstrate great clinical potentials of the MOPs for cancer theranostics.

尽管最近在肿瘤治疗方面取得了进展，但主要由于肿瘤微环境中的低氧，活性氧（ROS）介导的治疗，例如光动力疗法（PDT）和化学动力疗法（CDT），仍然具有挑战性。减轻肿瘤组织的缺氧已被认为是增强基于ROS的癌症治疗效果的有吸引力的策略。本文中，开发了一种级联平台来克服肿瘤缺氧并协同增强ROS介导的治疗效果。该平台基于可裂解的双金属金属有机聚合物（DOX @ Fe / Mn-THPP _TK -PEG）。作为一种高效的Fenton样材料，它不仅可以通过催化细胞内H ₂ O ₂的分解产生细胞毒性•OH ，还可以产生O ₂减轻肿瘤缺氧。此外，将DOX负载的金属有机聚合物（MOPs在暴露于激光照射或/和用H ₂ O ₂处理后可能会被破坏，然后释放DOX进行化学疗法。总体而言，有3种疗法（缺氧缓解PDT，照片这样的智能平台可以同时实现增强的CDT和ROS介导的化学疗法，并且在H ₂ O ₂处理下可以极大地提高MOP的T ₁加权MRI成像能力，因此共有四种强大的功能这些发现证明了MOP在癌症治疗中的巨大临床潜力。