An electrochemical method for discriminating healthy and malignant tissues in prostate biopsies using the voltammetry of immobilized particles methodology is described. The method involves the sampling with graphite bars 0.5 mm in diameter on paraffin-impregnated cross sections of prostate tissues used in ordinary cytological evaluation after local staining with methylene blue (MB). The subsequent record of the voltammetric response of sample-modified graphite electrodes displays clearly different MB-centered features for healthy and malignant regions due to the different association of the dye to the respective cells.

中文翻译：

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VIMP的生物医学应用：筛查前列腺中的恶性细胞

描述了使用固定颗粒伏安法测定前列腺活检中健康和恶性组织的电化学方法。该方法包括在亚甲基蓝（MB）局部染色后，在普通组织细胞学评估中使用的前列腺组织石蜡浸渍的横截面上，用直径0.5 mm的石墨棒进行采样。样品修饰的石墨电极的伏安响应的后续记录显示，由于染料与各个细胞的关联不同，因此健康和恶性区域的MB中心特征明显不同。