Estrogen related receptors (ERRα, β and γ in mammals) are orphan members of the nuclear receptor superfamily acting as transcription factors. ERRs are expressed in several tissues and cells and they display various physiological and pathological functions, controlling, amongst others and depending on the receptor, bone homeostasis, energy metabolism, embryonic stem cell pluripotency, and cancer progression. In contrast to classical nuclear receptors, the activities of the ERRs are not controlled by a natural ligand. Regulation of their activities thus rely on other means such as post-translational modification or availability of transcriptional co-regulators. In addition, regulation of their mere expression under given physiological or pathological conditions is a particularly important level of control. Here we discuss the mechanisms involved in the regulation of ERRs expression and the reported means to impact on it using pharmacological approaches.

中文翻译：

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雌激素相关受体（ERR）表达的调节。


雌激素相关受体（哺乳动物中的 ERRα、β 和 γ）是核受体超家族的孤儿成员，充当转录因子。 ERR 在多种组织和细胞中表达，它们表现出各种生理和病理功能，控制并依赖于受体、骨稳态、能量代谢、胚胎干细胞多能性和癌症进展。与经典核受体相反，ERR 的活性不受天然配体控制。因此，对其活动的调节依赖于其他手段，例如翻译后修饰或转录共调节因子的可用性。此外，在给定的生理或病理条件下对其表达的调节是特别重要的控制水平。在这里，我们讨论 ERR 表达调节所涉及的机制以及已报道的使用药理学方法对其产生影响的方法。