Progression through dissemination to tumor-surrounding tissues and metastasis development is a hallmark of cancer that requires continuous cell-to-cell interactions and tissue remodeling. In fact, metastization can be regarded as a tissue disease orchestrated by cancer cells, leading to neoplastic colonization of new organs. Collagen is a major component of the extracellular matrix (ECM), and increasing evidence suggests that it has an important role in cancer progression and metastasis. Desmoplasia and collagen biomarkers have been associated with relapse and death in cancer patients. Despite the increasing interest in ECM and in the desmoplastic process in tumor microenvironment as prognostic factors and therapeutic targets in cancer, further research is required for a better understanding of these aspects of cancer biology. In this review, published evidence correlating collagen with cancer prognosis is retrieved and analyzed, and the role of collagen and its fragments in cancer pathophysiology is discussed.

中文翻译：

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胶原生物学进入癌症进展和转移的预后和治疗

通过传播到肿瘤周围组织和转移发展而进展是癌症的一个标志，需要持续的细胞间相互作用和组织重塑。事实上，转移可以被视为一种由癌细胞精心策划的组织疾病，导致新器官的肿瘤定植。胶原蛋白是细胞外基质 (ECM) 的主要成分，越来越多的证据表明它在癌症进展和转移中起着重要作用。结缔组织增生和胶原生物标志物与癌症患者的复发和死亡有关。尽管人们对 ECM 和肿瘤微环境中的促纤维增生过程作为癌症的预后因素和治疗靶点越来越感兴趣，但仍需要进一步研究以更好地了解癌症生物学的这些方面。在这次审查中，