Age-related macular degeneration (AMD) is a devastating retinal degenerative disease. Epidemiological reports showed an expected increasing prevalence of AMD in the near future. The only one existing FDA-approved pharmacological treatment involves an anti-vascular endothelial growth factor (VEGF) therapy with serious disadvantages. This limitation emphasizes an alarming need to develop new therapeutic approaches to prevent and treat AMD. In this review, we summarize scientific data unraveling the therapeutic potential of the specific retinoid and natural compounds. The experimental results reported by us and other research groups demonstrated that retinoid analogs and compounds with natural product scaffolds could serve as lead compounds for the development of new therapeutic agents with potential to prevent or slow down the pathogenesis of AMD.

中文翻译：

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类维生素A类似物和多酚作为年龄相关性黄斑变性的潜在疗法。

年龄相关性黄斑变性（AMD）是一种毁灭性的视网膜退行性疾病。流行病学报告显示，AMD 的患病率预计在不久的将来将会增加。目前 FDA 批准的唯一一种药物治疗方法是抗血管内皮生长因子 (VEGF) 疗法，但该疗法存在严重缺点。这一限制强调了开发新的治疗方法来预防和治疗 AMD 的迫切需要。在这篇综述中，我们总结了科学数据，揭示了特定类维生素A和天然化合物的治疗潜力。我们和其他研究小组报告的实验结果表明，类维生素A类似物和具有天然产物支架的化合物可以作为开发新治疗剂的先导化合物，有可能预防或减缓AMD的发病机制。