Sleep problems have a negative impact on a range of outcomes and are very common in adolescents with chronic fatigue syndrome (CFS). We aimed to (a) establish whether adolescents with CFS have more self-reported sleep problems than illness controls as well as healthy controls, (b) investigate changes in sleep problems and (c) explore the extent to which sleep problems at baseline predict fatigue and functioning at follow-up in adolescents with CFS. The Insomnia Scale was completed by 121 adolescents with CFS, 78 healthy adolescents and 27 adolescents with asthma. Eighty (66%) treatment-naïve adolescents with CFS completed questionnaires approximately 3 months later. Adolescents with CFS reported increased sleep problems compared to healthy controls and adolescents with asthma. In CFS, there was no significant change in sleep problems without treatment over a 3-month follow-up. Sleep problems at baseline predicted a significant proportion of the variance in sleep problems at follow-up. Sleep problems should be targeted in treatment. Regulating the ‘body clock’ via the regulation of sleep could influence outcomes not assessed in this study such as school attainment.

中文翻译：

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CFS 青少年的睡眠问题：嵌套在前瞻性临床队列中的病例对照研究

睡眠问题会对一系列结果产生负面影响，并且在患有慢性疲劳综合症 (CFS) 的青少年中非常常见。我们的目的是 (a) 确定患有 CFS 的青少年是否比疾病对照组和健康对照组有更多的自我报告的睡眠问题，(b) 调查睡眠问题的变化，以及 (c) 探索基线睡眠问题在多大程度上预测疲劳和 CFS 青少年随访时的功能。失眠量表由 121 名患有 CFS 的青少年、78 名健康青少年和 27 名患有哮喘的青少年完成。大约 3 个月后，八十名 (66%) 未经治疗的 CFS 青少年完成了问卷调查。与健康对照组和患有哮喘的青少年相比，患有 CFS 的青少年报告的睡眠问题有所增加。在 CFS 中，在 3 个月的随访中，未经治疗的睡眠问题没有显着变化。基线时的睡眠问题预测了随访时睡眠问题差异的很大一部分。睡眠问题应有针对性地治疗。通过调节睡眠来调节“生物钟”可能会影响本研究中未评估的结果，例如学业成绩。